FB49

FB49 is a selective BAG3 inhibitor (Ki = 45 μM) that suppresses tumor cell proliferation, specifically inducing G1 cell cycle arrest, apoptosis, and autophagy in medulloblastoma models like HD-MB03 cells, while sparing normal peripheral mononuclear cells. Its mechanism supports research in oncology, particularly for studying protein quality control and cell death pathways in vitro.