HDAC6-IN-22

HDAC6-IN-22 (compound 30) is a potent and selective HDAC6 inhibitor with an IC50 of 4.63 nM. It demonstrates robust antiproliferative activity against multiple myeloma models by inducing G2/M phase cell cycle arrest and initiating mitochondrial apoptosis. This efficacy has been validated in both cellular assays and animal studies, supporting its use as a chemical probe in oncology and epigenetics research.