USP1-IN-5
USP1-IN-5 (compound 10) is a potent small molecule inhibitor of the deubiquitinase USP1, demonstrating IC50 values below 50 nM in both enzymatic and cellular (MDA-MB-436) assays. This inhibitor is a valuable research tool for studying DNA damage repair pathways and has been utilized in vitro to explore synthetic lethality in BRCA1-deficient cancer models.
Product Specifications
CAS Number
2925547-94-8
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry
Smiles
CN1C (C23C4C5C2C6C3C4C56CN7C=8C (C=N7) =CN=C (N8) C=9C (=NC=NC9OC) C%10CC%10) =NC (C (F) (F) F) =C1
Molecular Formula
C27H23F3N8O
Molecular Weight
532.52
Storage Conditions
-20°C
Notes
For research use only.
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