KRAS G12C inhibitor 61
This potent KRAS G12C inhibitor (Example 3) exhibits an IC50 of 9 nM for phospho-ERK inhibition in MIA PaCa-2 cells. It is a valuable research tool for studying KRAS-driven cancers, including pancreatic, colorectal, and non-small cell lung cancer, in both in vitro and in vivo models.
Product Specifications
CAS Number
2300967-40-0
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1N (C=2C (C (=N1) N3C (C) CN (C (C=C) =O) C (C) C3) =CC (Cl) =C (N2) C4=C (F) C=CC=C4N) C5=C (C (C) C) N=CC=C5C
Molecular Formula
C31H33ClFN7O2
Molecular Weight
590.09
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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