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SMD-3040

SMD-3040 is a potent and selective SMARCA2 PROTAC degrader with a DC50 of 12 nM. It achieves robust SMARCA2 degradation over SMARCA4 and has demonstrated significant tumor growth inhibition in xenograft models, supporting its use in oncology and targeted protein degradation research.

Product Specifications

CAS Number

3033109-92-8

Field of Research

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Purity

99.91% (May vary between batches)

Smiles

C (N1CC2 (C1) CCC (CC2) N3C=C (C=N3) C=4C=C (N=NC4N) C5=C (O) C=CC=C5) [C@H]6CC[C@H] (C (N[C@H] (C (=O) N7[C@H] (C (N[C@@H] (C) C8=CC=C (C=C8) C9=C (C) N=CS9) =O) C[C@@H] (O) C7) C (C) (C) C) =O) CC6

Molecular Formula

C52H66N10O5S

Molecular Weight

943.21

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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