Cbl-b-IN-6
Cbl-b-IN-6 (Compound 246) is a potent dual inhibitor of the E3 ubiquitin ligases Cbl-b and c-Cbl, with IC50 values of 6.7 nM and 5.2 nM, respectively. This small molecule is a valuable research tool for investigating immune cell signaling and has been utilized in both in vitro and in vivo studies exploring T-cell activation and potential immunotherapeutic applications.
Product Specifications
CAS Number
2815221-33-9
Field of Research
Cancer Biology, Protein Biochemistry
Smiles
C (C1 (CC (F) (F) C1) C2=CC (=CC=C2) N3CC=4C (C3=O) =CC ([C@@H] (NC5 (C) CCC5) C) =CC4C (F) (F) F) C=6N (C) C=NN6
Molecular Formula
C30H32F5N5O
Molecular Weight
573.6
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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