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OXA (17-33)

OXA (17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA (17-33) shows a ∼23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM) [1].

Product Specifications

CAS Number

[343268-91-7]

Product Name Alternative

Orexin A (17-33) (human, mouse, rat, bovine)

UNSPSC

12352209

Target

Orexin Receptor (OX Receptor)

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/oxa-17-33.html

Purity

97.48

Solubility

H2O : ≥ 12.5 mg/mL

Smiles

OC(C=C1)=CC=C1C[C@H](N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CN=CN2)C(NCC(N[C@@H](C)C(NCC(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@H](C(N)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C79H125N23O22

Molecular Weight

1748.98

References & Citations

[1]German NA, et al. Truncated Orexin Peptides: Structure-Activity Relationship Studies. ACS Med Chem Lett. 2013;4 (12) :1224-1227.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

OX1 Receptor; OX2 Receptor

Available Sizes

Curated Selection

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