Sp-Adenosine-5'-O- (1-thiotriphosphate) sodium
Sp-Adenosine-5'-O- (1-thiotriphosphate) (Sp-ATP-α-S) is a potent and selective P2Y1 receptor agonist. It mobilizes calcium in vitro (EC50 = 9.4 nM at human P2Y1) and inhibits platelet aggregation (Ki = 4 μM) . This tool compound is used in cardiovascular and smooth muscle research, including ex vivo studies like guinea pig taenia coli relaxation (EC50 = 426 nM) .
Product Specifications
Field of Research
Pharmacology & Drug Discovery
Smiles
O[C@@H]1[C@@H] (CO[P@@] (OP (OP ([O-]) ([O-]) =O) ([O-]) =O) ([S-]) =O) O[C@@H] (N2C3=NC=NC (N) =C3N=C2) [C@@H]1O.[Na+].[Na+].[Na+].[Na+]
Molecular Formula
C10H12N5O12P3S.4Na
Molecular Weight
611.18
Storage Conditions
-20°C
Notes
For research use only.
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