ARB-272572 hydrochloride
ARB-272572 hydrochloride is a potent small-molecule inhibitor of the PD-1/PD-L1 interaction, demonstrating an IC50 of 400 pM in HTRF assays. It functions by inducing PD-L1 dimerization to block the immune checkpoint pathway, making it a valuable tool for in vitro and in vivo cancer immunology research.
Product Specifications
CAS Number
2377524-19-9
Product Name Alternative
PD-1, PD1, PD1/PDL1, ARB-272572 hydrochloride (2368182-63-0 Free base), ARB272572hydrochloride (2368182630Freebase), PDL1, PD-L1
Field of Research
Cell Biology, Immunology & Inflammation
Purity
99.38% (May vary between batches)
Smiles
Cl.O=C (NC1=CC=CC (C=2C=CC=C (NC (=O) C3=NC=C (C=C3) CNCCO) C2C) =C1C) C4=NC=C (C=C4) CNCCO xHCl
Molecular Formula
C32H36N6O4.xClH
Molecular Weight
568.68 (Free base)
Storage Conditions
-20°C
Notes
For research use only.
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