AMG-548 hydrochloride (864249-60-5 free base)

AMG-548 hydrochloride is a potent, orally bioavailable, and highly selective p38α MAP kinase inhibitor (Ki = 0.5 nM) . It demonstrates significant selectivity over p38β and excellent potency in cellular assays, such as inhibiting LPS-induced TNFα production in human whole blood (IC50 = 3 nM) . This profile makes it a valuable research tool for investigating p38α's role in inflammation and autoimmune diseases in both in vitro and in vivo models.