DM3
DM3 is a maytansinoid derivative featuring a disulfide or thiol linker, which functions as a potent tubulin polymerization inhibitor. It is widely employed as the cytotoxic payload in antibody-drug conjugates (ADCs) for targeted cancer therapy research, with applications in both in vitro cytotoxicity assays and in vivo xenograft model studies.
Product Specifications
CAS Number
796073-54-6
Field of Research
Signal Transduction
Smiles
[H][C@@]12C[C@@] (O) (NC (=O) O1) [C@] ([H]) (OC) \C=C/C=C (C) \Cc1cc (OC) c (Cl) c (c1) N (C) C (=O) C[C@] ([H]) (OC (=O) [C@H] (C) N (C) C (=O) CCC (C) S) [C@]1 (C) O[C@H]1[C@@H]2C
Molecular Formula
C37H52ClN3O10S
Molecular Weight
766.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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