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Isofistularin-3

Isofistularin-3 is a direct, DNA-competitive inhibitor of DNMT1 (IC50 = 13.5 μM) that acts as a DNA demethylating agent. Its mechanism induces cell cycle arrest and sensitizes cancer cells to TRAIL-induced apoptosis in vitro, supporting its investigation as a potential cytotoxin for antibody-drug conjugates (ADCs) in oncology research.

Product Specifications

Field of Research

Cell Biology, Epigenetics & Chromatin

Smiles

COC1=C (Br) [C@H] (O) [C@@]2 (ON=C (C (NC[C@H] (O) COC3=C (Br) C=C ([C@H] (O) CNC (C4=NO[C@]5 (C4) C=C (Br) C (OC) =C (Br) [C@H]5O) =O) C=C3Br) =O) C2) C=C1Br

Molecular Formula

C31H30Br6N4O11

Molecular Weight

1114.01

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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