Leptomycin A
Leptomycin A is a Streptomyces-derived CRM1 (exportin 1) inhibitor that blocks protein nuclear export by disrupting CRM1-NES interactions, thereby suppressing HIV-1 replication. It is a valuable research tool for studying nuclear export mechanisms in virology and oncology, with demonstrated activity in both in vitro and cellular assays.
Product Specifications
CAS Number
87081-36-5
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Smiles
C[C@H] (C\C=C\C (\C) =C\[C@@H] (C) C (=O) [C@@H] (C) [C@H] (O) [C@@H] (C) C\C (C) =C\C (O) =O) \C=C (\C) /C=C/[C@@H]1OC (=O) C=C[C@@H]1C
Molecular Formula
C32H46O6
Molecular Weight
526.7
Storage Conditions
-20°C
Notes
For research use only.
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