RS 39604
RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites[1].
Product Specifications
CAS Number
[167710-87-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rs-39604.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CS(=O)(NCCN1CCC(CCC(C2=CC(Cl)=C(N)C=C2OCC3=CC(OC)=CC(OC)=C3)=O)CC1)=O.Cl
Molecular Formula
C26H37Cl2N3O6S
Molecular Weight
590.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Hegde SS, et al. RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br J Pharmacol. 1995;115 (6) :1087-1095.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor; Apolipoprotein D
Available Sizes
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