HSDVHK-NH2 (TFA)
HSDVHK-NH2 TFA is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM) [1][2].
Product Specifications
UNSPSC
12352209
Target
Integrin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsdvhk-nh2-tfa.html
Solubility
H2O
Smiles
NCCCC[C@@H](C(N)=O)NC([C@H](CC1=CNC=N1)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H](CC2=CNC=N2)N)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
Molecular Formula
C32H49F3N12O11
Molecular Weight
834.80
References & Citations
[1]Yoonsuk Lee, et al. High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J Biomol Screen. 2004 Dec;9 (8) :687-94.|[2]Youngjin Choi, et al. Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics. 2010 Jan;10 (1) :72-80.|[3]Ji-Young Bang, et al. Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis. Mol Cell Proteomics. 2011 Aug;10 (8) :M110.005264.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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