FRF-06-057
FRF-06-057 is an ATP-allosteric EGFR inhibitor against wild-type and mutant EGFR, with IC50s of 17 nM (LR/TM), 29 nM (LR/TM/CS), 220 nM (LR), > 1000 nM (WT) respectively[1].
Product Specifications
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/frf-06-057.html
Smiles
O=C(C(N1C(C2=C(C1=O)C=CC=C2)=O)C3=CC=CC=C3)NC4=NC=CS4
Molecular Formula
C19H13N3O3S
Molecular Weight
363.39
References & Citations
[1]Wittlinger F, et al. Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors. J Med Chem. 2024 Dec 12;67 (23) :21438-21469.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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