INCB38579

INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM) . INCB38579 shows anti-inflammatory pain and anti-pruritic activities[1].

Product Specifications

CAS Number

[1246207-65-7]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/incb38579.html

Purity

99.33

Solubility

DMSO : 230 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(CC1CCCC1)N2CCC3=CC=C(C4=NC(N)=NC(N5CCN(C)CC5)=C4)C=C3C2

Molecular Formula

C25H34N6O

Molecular Weight

434.58

References & Citations

[1]Niu Shin, et al. INCB38579, a novel and potent histamine H₄ receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions. Eur J Pharmacol. 2012 Jan 30;675 (1-3) :47-56.