INCB38579
INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM) . INCB38579 shows anti-inflammatory pain and anti-pruritic activities[1].
Product Specifications
CAS Number
[1246207-65-7]
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/incb38579.html
Purity
99.33
Solubility
DMSO : 230 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CC1CCCC1)N2CCC3=CC=C(C4=NC(N)=NC(N5CCN(C)CC5)=C4)C=C3C2
Molecular Formula
C25H34N6O
Molecular Weight
434.58
References & Citations
[1]Niu Shin, et al. INCB38579, a novel and potent histamine H₄ receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions. Eur J Pharmacol. 2012 Jan 30;675 (1-3) :47-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H4 Receptor
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1019943-01 0.02 mg (E-Coli)
Recombinant Francisella tularensis subsp. novicida UPF0102 protein FTN_0424 (FTN_0424)
Ask
View Details