SN-38 glucuronide-d3
SN-38 glucuronide-d3 is deuterium labeled SN-38 glucuronide. SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer[1][2][3][4].
Product Specifications
UNSPSC
12352005
Target
Drug Metabolite; Isotope-Labeled Compounds
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C1C2=C(C=C3C4=NC5=CC=C(C=C5C(CC([2H])([2H])[2H])=C4CN31)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(O)=O)O)O)O)[C@@](CC)(C(OC2)=O)O
Molecular Formula
C28H25D3N2O11
Molecular Weight
571.55
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Atasilp C, et al. Determination of irinotecan, SN-38 and SN-38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients. J Clin Lab Anal. 2018 Jan;32 (1) :e22217.|[3]Pellock SJ, et al. Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018;293 (48) :18559-18573.|[4]Wallace BD, et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 2010 Nov 5;330 (6005) :831-5.|[5]Ohtsuka K, et al. Intracellular conversion of irinotecan to its active form, SN-38, by native carboxylesterase in human non-small cell lung cancer[J]. Lung Cancer, 2003, 41 (2) : 187-198.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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