(S) -Gossypol (acetic acid)

(S) -Gossypol is the isomer of a natural product Gossypol. (S) -Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.

Product Specifications

CAS Number

[1189561-66-7]

Product Name Alternative

(S) - (+) -Gossypol acetic acid

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/_S_-Gossypol-acetic-acid.html

Purity

98.39

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@@]1[C@@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O.CC(O)=O

Molecular Formula

C32H34O10

Molecular Weight

578.61

References & Citations

[1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-) -Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10 (22) :7757-63.