(S)-Gossypol (acetic acid)
Product Specifications
UNSPSC Description
(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
Target Antigen
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_S_-Gossypol-acetic-acid.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@@]1[C@@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O.CC(O)=O
Molecular Weight
578.61
References & Citations
[1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.Patent. US20220162561A1.|Cancer Lett. 2019 Oct 1;461:31-43. |Clin Transl Med. 2021 Jun;11(6):e467.|Patent. US20220162561A1.|Microb Pathog. 2024 Sep 21:106960.|Transbound Emerg Dis. 2023 Nov 11.|Nat Commun. 2023 Jun 10;14(1):3445.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15464D/S-Gossypol-acetic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15464D/S-Gossypol-acetic-acid-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
1189561-66-7
Available Sizes
Curated Selection
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