(S) -Gossypol (acetic acid)
(S) -Gossypol is the isomer of a natural product Gossypol. (S) -Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
Product Specifications
CAS Number
[1189561-66-7]
Product Name Alternative
(S) - (+) -Gossypol acetic acid
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_S_-Gossypol-acetic-acid.html
Purity
98.39
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@@]1[C@@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O.CC(O)=O
Molecular Formula
C32H34O10
Molecular Weight
578.61
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Bcl-2; Bcl-xL
Citation 01
Patent. US20220162561A1.|Microb Pathog. 2024 Sep 21:106960.|Toxics. 2025 Sep 9;13 (9) :763.|Transbound Emerg Dis. 2023 Nov 11:2023:9073566.
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