ACTH (1-17) (TFA)

ACTH (1-17) TFA, an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.

Product Specifications

Product Name Alternative

α1-17-ACTH (TFA)

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/acth-1-17-tfa.html

Purity

99.79

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CSCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)=O)C(C)C)=O)=O)CCCCN)=O)=O)CC2=CNC3=C2C=CC=C3)=O)CCCNC(N)=N)=O)CC4=CC=CC=C4)=O)CC5=CN=CN5)=O)CCC(O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CC6=CC=C(O)C=C6)=O)CO)=O.O=C(O)C(F)(F)F

Molecular Formula

C95H145N29O23S.C2HF3O2

Molecular Weight

2207.43

References & Citations

[1]Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand) . 1999 Nov;45 (7) :1029-34.|[2]Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19 (8) :361-3.|[3]Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34 (8) :1191-6.