(S) -GSK-3685032

(S) -GSK-3685032 is the isomer of GSK-3685032 (HY-139664), and can be used as an experimental control. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1].

Product Specifications

CAS Number

[2170142-58-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-gsk-3685032.html

Purity

98.82

Solubility

DMSO : 90 mg/mL (ultrasonic)

Smiles

N#CC1=C(N2CCC(CC2)N)N=C(C(C#N)=C1CC)S[C@@H](C3=CC=CC=C3)C(N)=O

Molecular Formula

C22H24N6OS

Molecular Weight

420.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Pappalardi MB, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2 (10) :1002-1017.