TFEB activator 1
Product Specifications
UNSPSC Description
TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1].
Target Antigen
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tfeb-activator-1.html
Smiles
O=C(/C=C/C1=CC=CC=C1OC)/C=C/C2=CC=CC=C2OC
Molecular Weight
294.34
References & Citations
[1]Song JX, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-135825/TFEB-activator-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-135825/TFEB-activator-1-SDS-MedChemExpress.pdf
CAS Number
39777-61-2
Available Sizes
Curated Selection
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