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TFEB activator 1

TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1].

Product Specifications

CAS Number

39777-61-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tfeb-activator-1.html

Purity

99.71

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(/C=C/C1=CC=CC=C1OC)/C=C/C2=CC=CC=C2OC

Molecular Formula

C19H18O3

Molecular Weight

294.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Song JX, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12 (8) :1372-89.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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