(S) -GNE-987
(S) -GNE-987 is a potent dual inhibitor of the BRD4 BD1 and BD2 bromodomains, exhibiting low nanomolar IC50 values. This small molecule serves as a critical warhead for constructing PROTAC-Antibody Conjugates (PACs), enabling targeted protein degradation research in both cellular and in vivo models for oncology and epigenetic studies.
Product Specifications
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
O=C ([C@H] (C[C@H] (O) C1) N1C ([C@@H] (NC (CCCCCCCCCCNC (C2=C (CS (=O) (C) =O) C=C (C (N (C3=NC=C (F) C=C3F) C4) =C2) C5=CN (C) C (C6=C5C4=CN6) =O) =O) =O) C (C) (C) C) =O) NCC7=CC=C (C (SC=N8) =C8C) C=C7
Molecular Formula
C56H67F2N9O8S2
Molecular Weight
1096.31
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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