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SI-109

SI-109 is a high-affinity, small-molecule inhibitor targeting the STAT3 SH2 domain with a Ki of 9 nM. It has demonstrated antitumor efficacy in both cellular assays and in vivo models, making it a valuable chemical probe for oncology research and investigating STAT3-driven signaling pathways.

Product Specifications

CAS Number

2429877-30-3

Field of Research

Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Smiles

O=C ([C@@H] (NC ([C@@H]1CC[C@H] (CCN (C (C) =O) C[C@@H]2NC (C3=CC (C=C (C (F) (P (O) (O) =O) F) C=C4) =C4N3) =O) N1C2=O) =O) CCC (N) =O) NC (C5=CC=CC=C5) C6=CC=CC=C6

Molecular Formula

C40H44F2N7O9P

Molecular Weight

835.79

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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