Pacritinib citrate
Pacritinib citrate is a potent inhibitor of JAK2 (IC50 ~23 nM) and FLT3 (IC50 ~22 nM), including their common oncogenic mutants. This small molecule is widely used in preclinical research for myelofibrosis and acute myeloid leukemia, demonstrating activity in both in vitro and in vivo models.
Product Specifications
CAS Number
1228923-42-9
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
OC (CC (O) (C (O) =O) CC (O) =O) =O.N1 (CCCC1) CCOc2c3cc (Nc4nc (c5cc (COC/C=C/COC3) ccc5) ccn4) cc2
Molecular Formula
C34H40N4O10
Molecular Weight
664.7
Storage Conditions
-20°C
Notes
For research use only.
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