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Pan-HCN-IN-1

Pan-HCN-IN-1 (J&J12e) is a potent and selective HCN1 channel blocker with an IC50 of 58 nM. It reduces the voltage sag response and increases EPSP summation in ex vivo brain slices, making it a valuable tool for studying HCN1's role in neuronal excitability, synaptic integration, and related neurological disorders in vitro.

Product Specifications

CAS Number

1334308-63-2

Field of Research

Pharmacology & Drug Discovery

Smiles

C (NC (=O) C1=C (OCC) C=CC=C1) C2 (CCCCC2) N3CCN (C (C) C) CC3

Molecular Formula

C23H37N3O2

Molecular Weight

387.56

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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