Pan-HCN-IN-1
Pan-HCN-IN-1 (J&J12e) is a potent and selective HCN1 channel blocker with an IC50 of 58 nM. It reduces the voltage sag response and increases EPSP summation in ex vivo brain slices, making it a valuable tool for studying HCN1's role in neuronal excitability, synaptic integration, and related neurological disorders in vitro.
Product Specifications
CAS Number
1334308-63-2
Field of Research
Pharmacology & Drug Discovery
Smiles
C (NC (=O) C1=C (OCC) C=CC=C1) C2 (CCCCC2) N3CCN (C (C) C) CC3
Molecular Formula
C23H37N3O2
Molecular Weight
387.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog