PI3K/HDAC-IN-3
PI3K/HDAC-IN-3 (36) is a potent dual inhibitor of PI3Kα (IC50=0.23 nM) and HDAC1 (IC50=172 nM) . It reduces p-AKT and increases acetyl-H3 in MV4-11 cells and shows dose-dependent antitumor efficacy in MV4-11 xenograft models, supporting its use in oncology research for hematological malignancies.
Product Specifications
CAS Number
3006905-22-9
Field of Research
Epigenetics & Chromatin, Molecular Biology, Signal Transduction
Smiles
O (CCCCCCC (NC1=C (N) C=CC=C1) =O) C=2C3=C (C=C (C2) C=4C=C (NS (=O) (=O) C5=C (F) C=C (F) C=C5) C (OC) =NC4) C (C) =NC=N3
Molecular Formula
C34H34F2N6O5S
Molecular Weight
676.73
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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