PLK1-IN-10
PLK1-IN-10 (Compound 4Bb) is an orally bioavailable small molecule that targets the PLK1 polo-box domain, disrupting its interaction with PRC1 and downregulating CDK1-Cyclin B1. It also induces oxidative stress via glutathione interaction, promoting cell death in cancer research models, supporting its use in both in vitro and in vivo oncological studies.
Product Specifications
CAS Number
2991469-21-5
Field of Research
Cell Biology, Signal Transduction
Smiles
S (NCC1=CC=C (F) C=C1) (=O) (=O) C=2C3=C4C (C (=O) N (CCN (C) C) C (=O) C4=CC=C3) =CC2
Molecular Formula
C23H22FN3O4S
Molecular Weight
455.50
Storage Conditions
-20°C
Notes
For research use only.
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