PM534
PM534 is a potent colchicine-site tubulin inhibitor that disrupts microtubule assembly with low nanomolar IC50 values (0.8-3.2 nM) . It demonstrates significant antitumor activity in cellular assays and has shown efficacy in vivo, making it a valuable chemical probe for cancer research and mechanism-of-action studies.
Product Specifications
CAS Number
2446376-25-4
Field of Research
Signal Transduction
Smiles
[C@@H] (NC (=O) [C@@]1 (C) N=C (\C (=N\O) \C) SC1) (CCC) C2=CC (OCC3CC3) =CC (=O) O2
Molecular Formula
C20H27N3O5S
Molecular Weight
421.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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