PROTAC AR/AR-V7 degrader-1
PROTAC AR/AR-V7 degrader-1 (27c) is a bifunctional small molecule that simultaneously degrades full-length AR and the AR-V7 splice variant, with DC50 values of approximately 2.7 μM. It induces apoptosis and is a valuable chemical tool for studying androgen receptor signaling and resistance mechanisms in prostate cancer research, both in vitro and in vivo.
Product Specifications
CAS Number
2841308-96-9
Field of Research
Cell Biology, Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C1N (C (=O) C (C) (C) N1CCNC=2C3=C (C (F) =CC2) N=CC=C3) C4=CC (C (F) (F) F) =C (C#N) C=C4
Molecular Formula
C24H19F4N5O2
Molecular Weight
485.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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