PROTAC ERα Degrader-8
PROTAC ERα Degrader-8 (compound ii-56) is a potent, small-molecule degrader of the estrogen receptor alpha (ERα), demonstrating high cellular potency with a DC50 of 6 pM in MCF7 breast cancer cells. This tool compound is valuable for investigating targeted protein degradation in ER+ breast cancer models, both in vitro and in vivo.
Product Specifications
CAS Number
3025533-68-7
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
OC=1C=C2C ([C@@H] ([C@@H] (CC2) C3=CC=CC=C3) C4=CC=C (C=C4) N5C6 (CC (CN7CCN (CC7) C=8C=C9C (=CC8) C (=O) N (C9) [C@@H]%10C (=O) NC (=O) CC%10) CC5 (CC6) [H]) [H]) =CC1
Molecular Formula
C47H51N5O4
Molecular Weight
749.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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