PROTAC KRAS G12C degrader-2
PROTAC KRAS G12C degrader-2 (compound 432) is a bifunctional molecule that recruits the E3 ligase cereblon to KRAS G12C, inducing its proteasomal degradation. This tool compound enables the study of KRAS-driven oncogenesis and is applicable in both cellular and in vivo models for targeted protein degradation research.
Product Specifications
CAS Number
2378257-72-6
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
FC=1C2=C (C (=NC (O[C@@H] (CN3CCN (CC4CCN (CC4) C=5C=C6C (=CC5) C (=O) N (C6=O) C7C (=O) NC (=O) CC7) CC3) C) =N2) N8CCN (C (C=C) =O) CC8) C=C (Cl) C1C=9C%10=C (C=C (O) C9) C=CC=C%10
Molecular Formula
C51H53ClFN9O7
Molecular Weight
958.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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