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PROTAC SMARCA2 degrader-3

PROTAC SMARCA2 degrader-3 (Compound 153) is a heterobifunctional small molecule that selectively targets and degrades the SMARCA2 (BRM) ATPase subunit of the SWI/SNF chromatin remodeling complex. It is a valuable chemical probe for investigating SWI/SNF biology and has demonstrated anticancer activity in both cellular and in vivo preclinical studies.

Product Specifications

CAS Number

3024266-69-8

Field of Research

Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery

Smiles

O=C1C (N2C=3C (=C (C=CC3) [C@@H]4CC[C@@H] (CC4) N5CCC (CC5) N6C=C (C=N6) C=7C=C (N=NC7N) C8=C (O) C=CC=C8) OCC2) CCC (=O) N1

Molecular Formula

C37H42N8O4

Molecular Weight

662.78

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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