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PROTAC SOS1 degrader-5

PROTAC SOS1 degrader-5 (compound 4) potently degrades SOS1 with a DC50 of 13 nM and inhibits NCI-H358 cell proliferation with an IC50 of 5 nM. This molecule is a valuable chemical probe for investigating SOS1-dependent RAS signaling in cancer research, both in vitro and in vivo.

Product Specifications

CAS Number

2836273-61-9

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Smiles

C (OC1=CC2=C (C=C1OC) N=C (C) N=C2N[C@H] (C) C3=CC (C (F) (F) F) =CC (N) =C3) C4 (CN (C (CCCCCCNC5=C6C (C (=O) N (C6=O) C7C (=O) NC (=O) CC7) =CC=C5) =O) C) CC4

Molecular Formula

C45H51F3N8O7

Molecular Weight

872.93

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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