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SIK-IN-2

SIK-IN-2 (Compound 45) is a highly potent, pan-SIK inhibitor with single-digit nanomolar IC50 values against SIK1, SIK2, and SIK3. It modulates macrophage cytokine profiles by potently suppressing TNFα and enhancing LPS-induced IL-10 release, making it a valuable tool for studying SIK signaling in inflammation and immunometabolism in cellular models.

Product Specifications

CAS Number

3033846-20-4

Field of Research

Epigenetics & Chromatin, Signal Transduction

Smiles

C (#N) C=1N2C (=CN=C2C=CC1N) C3=CC (OCC4 (N) CCCC4) =C (C#N) C (SC) =C3

Molecular Formula

C22H22N6OS

Molecular Weight

418.52

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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