Soquelitinib
Soquelitinib (CPI-818) is an oral, covalent inhibitor of ITK that selectively reduces Th2 cytokine production. It demonstrates anti-tumor activity in mouse models by modulating T-cell function, reducing exhaustion markers, and enhancing tumor infiltration alongside the upregulation of CXCR3, IFNγ, and CD107a in CD8+ T cells. This profile supports its research use in immunology and oncology for studying T-cell-mediated responses.
Product Specifications
CAS Number
2226636-04-8
Product Name Alternative
CPI818, CPI-818
Field of Research
Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.54% (May vary between batches)
Solubility
DMSO:80 mg/mL (155.44 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (19.43 mM)
Smiles
C (=O) (C1=C (OC) C=C (C) C (SC=2SC (NC (=O) C3CC3) =NC2) =C1) N4C[C@@H] (C) N (C (C=C) =O) CCC4
Molecular Formula
C25H30N4O4S2
Molecular Weight
514.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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