TNG348
TNG348 is a selective, reversible USP1 inhibitor that disrupts RAD18-dependent translesion synthesis, leading to ubiquitinated substrate accumulation. It exhibits synergistic antitumor activity with PARP inhibitors in HR-deficient models, offering a distinct mechanism for targeting DNA damage repair pathways in cancer research.
Product Specifications
CAS Number
2839740-79-1
Product Name Alternative
TNG 348, TNG-348
Field of Research
Cell Biology, Molecular Biology, Protein Biochemistry
Purity
98.67% (May vary between batches)
Solubility
DMSO:80 mg/mL (132.56 mM)
Smiles
FC (F) (F) C=1N=C (C=2C=CC (=CC2) CN3C4=NC (=NC=C4N (C3=N) CC (F) (F) F) C=5C (=NC=NC5C6CC6) OC) N (C1) C
Molecular Formula
C27H23F6N9O
Molecular Weight
603.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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