PROTAC VHL-type degrader-1
PROTACVHL-type degrader-1 is a VHL-recruiting PROTAC that induces ATM degradation. This activity synergizes with the ATR inhibitor AZD6738, a combination studied in vitro for cancer research, particularly in the context of DNA damage response pathways.
Product Specifications
CAS Number
2821804-13-9
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
O=C1\C (\C=2C (N1CCCC3=CN (CCCCCC (N[C@H] (C (=O) N4[C@H] (C (NCC5=CC=C (C=C5) C6=C (C) N=CS6) =O) C[C@@H] (O) C4) C (C) (C) C) =O) N=N3) =CC=CC2) =C\7/C=8C (NC7=O) =CC=CC8
Molecular Formula
C49H55N9O6S
Molecular Weight
898.08
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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