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3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles

This small molecule is a dual inhibitor of BMP2 (IC50 = 2.2 μM) and MEK1. It has demonstrated anti-inflammatory and neuroprotective activity in the EAE mouse model, supporting its use in research on neuroinflammation, bone biology, and MAPK/MEK signaling pathways.

Product Specifications

CAS Number

287196-91-2

Field of Research

Signal Transduction, Stem Cell & Developmental Biology

Smiles

N#CC=1C (=O) NSC1NC=2C=CC=CC2C (F) (F) F

Molecular Formula

C11H6F3N3OS

Molecular Weight

285.25

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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