SD-36 TFA
SD-36 (TFA) is a potent and selective STAT3 degrader (Kd ~50 nM) that inhibits STAT3 transcription and degrades mutant STAT3 proteins. It demonstrates anticancer activity in vitro and in vivo, inducing apoptosis and growth inhibition in glioblastoma models through suppression of Mcl-1.
Product Specifications
Product Name Alternative
Apoptosis, STAT3, SD36 TFA, SD-36 TFA (2429877-44-9 Free base), SD36TFA (2429877449Freebase), SD 36 TFA
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.43% (May vary between batches)
Solubility
DMSO:150 mg/mL (117.91 mM)
Smiles
O=C (NC (C1=CC=CC=C1) C2=CC=CC=C2) [C@H] (CCC (N) =O) NC ([C@H]3N4[C@] (CCN (C[C@@H] (C4=O) NC (C5=CC6=CC (C (F) (F) P (O) (O) =O) =CC=C6N5) =O) C (CCCCCC#CC7=C8C (C (N (C9C (NC (CC9) =O) =O) C8) =O) =CC=C7) =O) ([H]) CC3) =O.OC (C (F) (F) F) =O
Molecular Formula
C61H63F5N9O14P
Molecular Weight
1272.17
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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