Lumicitabine

Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase.

Product Specifications

CAS Number

[1445385-02-3]

Product Name Alternative

ALS-008176; ALS-8176

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H341

Target

RSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ALS-8176.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : ≥ 50 mg/mL

Smiles

ClC[C@@]1(COC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@@H](F)[C@H](N2C(N=C(N)C=C2)=O)O1

Molecular Formula

C18H25ClFN3O6

Molecular Weight

433.86

Precautions

H301, H311, H331, H341

References & Citations

[1]DeVincenzo JP, et al. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study. N Engl J Med. 2015 Nov 19;373 (21) :2048-58.|[2]Wang G, et al. Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J Med Chem. 2015 Feb 26;58 (4) :1862-78.