Lumicitabine
Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase.
Product Specifications
CAS Number
1445385-02-3
Product Name Alternative
ALS-008176; ALS-8176
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
RSV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ALS-8176.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : ≥ 50 mg/mL
Smiles
ClC[C@@]1(COC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@@H](F)[C@H](N2C(N=C(N)C=C2)=O)O1
Molecular Formula
C18H25ClFN3O6
Molecular Weight
433.86
Precautions
H301, H311, H331, H341
References & Citations
[1]DeVincenzo JP, et al. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study. N Engl J Med. 2015 Nov 19;373 (21) :2048-58.|[2]Wang G, et al. Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J Med Chem. 2015 Feb 26;58 (4) :1862-78.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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