MC-Val-Cit-PAB-Exatecan
MC-Val-Cit-PAB-Exatecan is a cathepsin-cleavable drug-linker conjugate incorporating the potent topoisomerase I inhibitor DX-8951 (Exatecan) . It is designed for constructing antibody-drug conjugates (ADCs) and is used in research to evaluate targeted cytotoxicity in both in vitro and in vivo cancer models.
Product Specifications
CAS Number
2504068-28-2
Product Name Alternative
DrugLinkerConjugatesforADC, DrugLinker Conjugates for ADC, MC-Val-Cit-PAB-DX 8951, MC-Val-Cit-PAB-DX8951, MC-Val-Cit-PAB-DX-8951, MC-Val-Cit-PAB-Exatecan
Field of Research
Molecular Biology, Pharmacology & Drug Discovery
Purity
98.03% (May vary between batches)
Solubility
DMSO:80 mg/mL (77.36 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (0.97 mM)
Smiles
N (C (OCC1=CC=C (NC ([C@@H] (NC ([C@@H] (NC (CCCCCN2C (=O) C=CC2=O) =O) [C@H] (C) C) =O) CCCNC (N) =O) =O) C=C1) =O) [C@@H]3C4=C5C (C=6N (C5) C (=O) C7=C (C6) [C@] (CC) (O) C (=O) OC7) =NC=8C4=C (CC3) C (C) =C (F) C8
Molecular Formula
C53H60FN9O12
Molecular Weight
1034.09
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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