Sulfathiazole (sodium)

Sulfathiazole sodium is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole sodium increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish. Sulfathiazole sodium is also a cathodic corrosion inhibitor. It inhibits the corrosion of copper by chloride ions through chemical and physical adsorption on the copper surface, reduces the corrosion current density and shifts the corrosion potential negatively[1][2][3].

Product Specifications

CAS Number

[144-74-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Sulfathiazole-sodium.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 140 mg/mL (ultrasonic) |H2O : 140 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(N)C=C1)([N-]C2=NC=CS2)=O.[Na+]

Molecular Formula

C9H8N3NaO2S2

Molecular Weight

277.30

Precautions

H315, H319, H335

References & Citations

[1]Ji K, Choi K, Lee S, Park S, Khim JS, Jo EH, Choi K, Zhang X, Giesy JP. Effects of sulfathiazole, oxytetracycline and chlortetracycline on steroidogenesis in the human adrenocarcinoma (H295R) cell line and freshwater fish Oryzias latipes. J Hazard Mater. 2010 Oct 15;182 (1-3) :494-502.|[2]Endicott, et al. Lesions in rats given sulfathiazole, sulfadiazine, sulfanilamide, sulfamerazine, sulfapyrazine, or acetylsulfadiazine in purified diets. Public Health Reports (1896-1970) (1944) : 49-54.|[3]Zor, et al. Sulfathiazole as potential corrosion inhibitor for copper in 0.1 M NaCl. Protection of Metals and Physical Chemistry of Surfaces 50 (2014) : 530-537.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Research Square Preprint. 2021 Aug.|ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Chemosphere. 2019 Jun:225:378-387.|Theranostics. 2022 Jan 1;12 (3) :1187-1203.