SIAIS164018 hydrochloride
SIAIS164018 hydrochloride is a potent PROTAC degrader of ALK and EGFR, with IC50 values of 2.5 nM for ALK and 6.6 nM for the ALK G1202R mutant. It demonstrates robust anti-cancer activity in vitro by inhibiting cell migration and invasion, inducing G1 phase arrest, and promoting apoptosis, outperforming brigatinib in these assays.
Product Specifications
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C43H49Cl2N10O7P
Molecular Weight
919.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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